Will it work with lowrance HDS gen 2 units?

No, this is only for Garmin units.  You'll need to use a Lowrance brand radar for Lowrance units.  The equivelant Lowrance dome would be the Halo20, here is a link to it https://www.boemarine.com/lowrance-halo20-20-radar-dome-w-5m-cable-1.html